Prospera Specification Sheet

Reliable, Broad Assessment of Active Rejection

Analytical Validation of a Single-Nucleotide Polymorphism-Based Donor-Derived Cell-Free DNA Assay for Detecting Rejection in Kidney Transplant Patients

Transplantation. 2019 Feb 19.

Altug, Y.

This study validates the performance of a SNP-based mmPCR assay to detect the dd-cfDNA fraction with improved precision over currently available tests, regardless of donor-recipient relationships...

Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR

J Clin Med. 2018 Dec 23;8(1). pii: E19.

Sigdel, T.K. et al.

This study validates the use of dd-cfDNA in the blood as an accurate marker of kidney

Validation of a Clinical-Grade Assay to Measure Donor-Derived Cell-Free DNA in Solid Organ Transplant Recipients

J Mol Diagn. 2016 Nov;18(6):890-902.

Grskovic, M.

In summary, we have developed and analytically validated a clinical-grade NGS test to measure the fraction of dd-cfDNA in plasma of solid organ transplant patients. This test is applicable to single-organ donor-recipient pairs and does not depend on separate determination of either donor or recipient genotypes...