Validation of a Clinical-Grade Assay to Measure Donor-Derived Cell-Free DNA in Solid Organ Transplant Recipients
J Mol Diagn. 2016 Nov;18(6):890-902.
In summary, we have developed and analytically validated a clinical-grade NGS test to measure the fraction of dd-cfDNA in plasma of solid organ transplant patients. This test is applicable to single-organ donor-recipient pairs and does not depend on separate determination of either donor or recipient genotypes...